We aim to determine stroke prevalence and associated risk factors in Thawung hospital, Thawung district, Lopburi province. We collected demographic data, history taking, physical examination, laboratory results, and diagnosis of NCDs (hypertension, dyslipidemia, diabetes mellitus, heart diseases, chronic kidney disease ) patients from recorded computer data during the last five years (2016-2020), including age, gender, healthcare coverage, smoking, alcohol drinking, BMI, blood pressure, FBS, HbA1c, triglyceride, LDL, a provisional diagnosis of stroke (2016-2020), underlying hypertension, dyslipidemia, diabetes mellitus, heart diseases, chronic kidney disease in 3,777 patients. Descriptive statistics were used to analyze demographic data. In addition, logistic regression was used to determine the associated factors of stroke. The five-year prevalence of stroke among NCD patients in Thawung hospital was 9.3 %. The associated risk factors from the multivariable analysis were gender, age, BMI, hypertensive crisis (SBP ≥180 or DBP ≥110 mmHg), smoking, and alcohol drinking. Reasonable control of BMI and blood pressure could prevent stroke, while cessation of smoking and alcohol drinking are also significant risks. So, Public health interventions aimed at preventing and reducing stroke should be designed and provided.